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novoWorx™

As NGS continues to be one of the most popular tools in molecular biology, processing the massive amount of data generated can be quite an arduous task. Undeniably, NGS data analysis is at the heart of making sense of your big data. Running complex bioinformatics algorithm might take away a big chunk of your time causing unnecessary delays in research progress. Here’s the good news, we have a smart solution for you.

 

Introducing novoWorx™, a Next Generation Sequencing data management and analytics platform.

 

A comprehensive multi proprietary platform from Novocraft Technologies to accelerate your research by simplifying analysis using sophisticated, fully automated solutions powered by the latest technologies. The platform uses the best practice in running millions of reads to provide clear insights from your NGS data to drive your research further.

NGS Data Management and Analytics in a single platform

 

novoWorxTM is a comprehensive Genome Data Management and Analytics Platform to meet the growing need for working with large sequencing datasets. novoWorxTM is a combination of unique proprietary software and open source modules to decipher your big data into meaningful results. This product is accessed via a web browser and requires no coding for wet lab scientists to process NGS sequencing data in a user-friendly environment.

Why novoWorxTM?

 

  • The only commercially available tool to offer embedded novoalignTM and novosortTM programs for high-throughput bioinformatics analysis
  • A modular system for delivering canned genomics pipelines
  • Process large datasets consisting of multiple samples without programming knowledge
  • Generates all the outputs in standard formats required for downstream/tertiary analysis by other systems

Who should use novoWorxTM?

 

  • Academic labs
  • Small to midsize biotech companies
  • Discovery/Translational groups in Pharmaceutical companies
  • Core research labs in universities/hospitals

Features

 

We’re keeping it simple, so we maintain mostly primary NGS analysis in novoWorx™ with the following features:

  • Web-enabled and secure interface with access control
  • Drag and drop sequencing/other files into the interface
  • Supports multiple samples run from a single click, no coding required to loop through large sample collection sets
  • Integrated genome browser
  • Cluster-aware (SGE support) and monitor all running, pending and completed jobs (coming soon)
  • Result file downloads
  • Browse all files as reactive tables and figures (javascript)
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Streamlined, user-friendly interface for easy navigation

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View job status in real time.

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Advanced and detail-rich results.

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Ready to use downloadable results.

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Locate, manage and download your analysis results with ease.

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Integrated genome browser for easy viewing.

novoWorx™ Pipelines

novoAnalytics Suite

  • 1. Basic Next Generation Sequence Alignment and Sort with Mark Duplicates

    novoWorx™ basic NGS alignment and sort with mark duplicates is novoWorx™ free pipeline for aligning NGS reads to a known reference sequence. The pipeline incorporates our highly rated aligner novoAlign™ for reads alignments. Using the multithreaded sort and mark/remove duplicated reads feature available in novoSort™, it enables fast alignment sorting and marking/removal of possible read duplicates at the same time. The aligned and sorted NGS reads can be viewed on novoWorx™ genome browser (powered by JBrowse).

    For this version, we support human genome (HG19).

  • 2. Whole Genome Sequence (WGS) analysis

    novoWorx™ WGS alignment and basic small variant calling pipeline was designed for your ease of use in analysing your WGS reads. The pipeline incorporates our highly rated aligner novoAlign™ for reads alignments. Using the multithreaded sort and mark/remove duplicated reads feature available in novoSort™, it enables fast alignment sorting and marking/removal of possible read duplicates at the same time.  Small variants are called using Samtools variant caller. The aligned WGS reads and variants called by Samtools can be viewed on novoWorx™ genome browser (powered by JBrowse).

    For this version, we support human genome (HG19).

  • 3. Whole Exome Sequence (WES) analysis

    novoWorx™ WES alignment and basic small variant calling pipeline was designed for your ease of use in analysing your WES reads. The pipeline incorporates our highly rated aligner novoAlign™ for reads alignments. Using the multithreaded sort and mark/remove duplicated reads feature available in novoSort™, it enables fast alignment sorting and marking/removal of possible read duplicates at the same time. Small variants are called using Samtools variant caller.  The aligned WES reads and variants called by Samtools can be viewed on novoWorx™ genome browser (powered by JBrowse).

    The pipeline comes with novoAnalytics; an analysis suite for performing further analytics on your exome results. novoAnalytics tool available in this version:

    • Basic variant comparison in multisamples studies and Euler plot generation (max samples; 6)

  • 4. Targeted Amplicon Sequence (TAS) analysis

    novoWorx™ TAS alignment and basic small variant calling pipeline was designed for your ease of use in analysing your TAS reads. The pipeline incorporates our highly rated aligner novoAlign which has TAS aware features built in.

    TAS alignment using novoAlign™ in novoWorx™:

    (1) Automatically soft-clip primer regions if amplicon bed file is provided,

    (2) Hard-clip possible adaptor contamination in paired-reads through self-learning

    (3) Reports paired-reads mapping counts to the target region.

    Using the multithreading alignment sort feature available in novoSort™, it enables fast reads alignment sorting.  Small variants are called using Samtools variant caller. The aligned TAS reads and variants called by Samtools can be viewed on novoWorx™ genome browser (powered by JBrowse).

    The pipeline comes with novoAnalytics; an analysis suite for performing further analytics on your exome results. novoAnalytics tool available in this version:

    • Basic variant comparison in multisamples studies and Euler plot generation (max samples; 6)

  • 5. Basic RNA Alignment with Raw Count analysis (Coming soon)

    Coming Soon

  • 6. Basic miRNA Alignment with Raw Count analysis (Coming soon)

    Coming Soon

  • 7. Basic Bisulphite reads alignment (Coming soon)

    Coming Soon

Available Tool:

  1. Euler Plot

 

Upcoming Tools:

  1. novoAnnotator
  2. WES read coverage analysis
  3. TAS reads library assessment and coverage analysis

novoWorx™ Minimum Requirements

 

Minimum Recommended
CPU Dual core 1.8GHz OctaCore 3.2Ghz
Memory 8 GB DDR2 16GB DDR3
Storage Space 5GB for installation media*

50 GB post installation **

100GB free space ***

5GB for installation media*

50 GB post installation **

100GB free space ***

Network 500Kb/s Download Speed 1Mb/s Download Speed
Virtual Machine Environment Any Virtual Machine Environment capable of importing OVA files Oracle Virtualbox V4.2 and above (Recommended) or VMware

*only takes into account the OVA installation media

**post installation file size

 

Files Size
novoWorx

(Required)

novoWorx™ Databases 2GB
HG19 Reference files 18GB

*** Free space on your device or on a storage device where you will store your samples and outputs. File sizes are dependent on the data you have. This is not included in the 50GB required for novoWorx™ installation

Operating systems

 

novoWorx™ is fully supported on the following operating systems at the time of this release note publication:-

  1. Microsoft Windows 8 and above (up to Windows 10 Version 1511 build 10586.589)
  2. Debian Linux 7.0 and above
  3. Ubuntu Linux 14.04 and above
  4. Mac OS (Sierra 10.12)

 

Browsers

 

novoWorx™ is currently tested and built for Google Chrome Build 53.0.2785.116 m. Other browsers that are supported for novoWorx™ are:

  1. Chromium build 37.0.2062.120-1
  2. Vivaldi build 1.4.589.11 and above
  3. Mozilla Firefox 45.3.0
  4. Safari 5.1.10

 

The following browsers have been tested with novoWorx™ but have limited support until further releases

  1. Microsoft Edge (All builds)
  2. Opera (All builds)
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