Personalised medicine made easy
NGS Clinical and Wellness Analysis Platform
novoClinic is a patient-centric NGS targeted sequence analysis platform that provides integrated sample tracking for quality control and compliance. novoClinic resolves the burden of data mining and interpretation, allowing clinicians to focus on diagnosis and treatment.
The advancement of knowledge and the increasing availability of data in gene-disease or trait associations has brought personalized and precision medicine to the forefront. novoClinic is a simple, easy-to-use solution for healthcare providers who intends to engage genomic data as a primary diagnostic and decision-making tool to significantly improve disease treatment and patient’s management.
Why novoClinic?
- Single analysis platform from data QC to report generation.
- Powered by in-house developed software; novoAlign & novoSort, ensuring continuous support and maintenance.
- Time-saving and cost effective integrated analysis in a single platform.
- Features activity tracking, custom disease variant model and internal annotation & knowledge-base among others.
- Straight-forward data reporting system.
- Built-in customizable analysis of pipeline.
- Reproducible data allows accountability and continuity of processes.
Who should use novoClinic?
- Diagnostic laboratories
- Genetic screening and testing facilities
- Public and private hospitals / medical institutions
How It Works?
novoClinic is streamlining the process of genetic data reporting for Clinicians. It provides a clear workflow that facilitate the analysis process from input of raw sequencing data, data analysis, interpretation and a customizable report. Customers in both clinical and wellness sector will be able to provide a comprehensive report directly to their customers along with appropriate recommendation.
Key Features
Integrated Assay/Kit-Analysis Pipeline
novoClinic has everything you need to identify any disease-related variants and to screen patients’ wellness and health.
Custom Disease Variant Model
novoClinic is highly customisable giving the customers full control and more options in terms of disease or trait modelling.
NGS Pharmacogenomics Pipeline
novoClinic includes a pharmacogenomics pipeline that allows healthcare providers to personalize treatments, improving medication effectiveness and minimizing adverse effects.
Ancestry Composition Estimation
novoClinic includes an ancestry estimation analysis pipeline, allowing people to understand their genealogical information. This can help them connect with distant relatives and learn about their family’s origins.
Custom Report Generation
novoClinic lets customers decide how the report looks like as they are 100% customisable. It uses HTML and CSS for report template and can be download to PDF.
Internal Annotation & Knowledgebase
novoClinic allows customers to have customisable databases, as well as add their own internal notes to diseases/traits, genes and variants.
Clinical
Disease Gene-Variant Model
Over 300 clinical gene panels
Allows users to pick and use over 300 clinical gene panels and create their own model according to its business function.
Filter parameters
Set the cut-off values for parameters such as Variant Allele Frequency and Read Depth. The results can be filtered based on the variant significance.
Expression rules
Add the rule of expression to specify the mutation combination between genes / variants. Additional notes can be included to the expression rule as well.
Pharmacogenomics
NGS Pharmacogenomics Pipeline
Comprehensive Genomic Analysis
Perform SNPs detection, infer haplotypes and diplotypes, & genotype / phenotype of PGx genes, including complex genes, e.g., CYP2D6.
Curated Guideline Recommendations
Established guidelines from Clinical Pharmacogenetics Implementation Consortium (CPIC) and Dutch Pharmacogenetics Working Group (PharmGKB-DPWG)
Diverse Medications and Conditions
Provides medication guidance in various medical fields,such as gastroenterology, neurology, cardiology, psychiatry and oncology.
Wellness
Genetic Wellness Profiling
Personalised wellness modules and traits
Define and customize wellness modules and traits based on specific genetic variants.
Personalised recommendations
Provide tailored wellness recommendations based on the patient’s unique genetic profile.
Expression rules
Automatically classify traits into risk categories (e.g., high risk, low risk) based on the presence of defined variants in patient samples.
Ancestry
Ancestry Composition Estimation
Supervised learning based method
novoClinic predict the ancestry of an individual based on the individual’s variants located in autosomal chromosomes using supervised learning on the known ethnicities of individuals in 1000 Genomes phase III dataset and Singapore Sequencing Malay dataset.
Up to 25 populations in the world
novoClinic covers up to 25 populations worldwide from Asia, Africa, America and Europe, with more refined results as our database expands.
Secure & Customizable Report Generation
Decide how your report looks like as they are 100% customizable. Upload your HTML and CSS report format into novoClinic and generate a downloadable PDF report for your clients to download into their chosen devices.
- Customizable report template
- Selection tracking
- Multi-level verification
Available in:
Not familiar with HTML?
Take it easy. Contact us and and our team will create one for you.
User friendly interface – no coding required
Break the code barrier. Run your analysis faster without having to code.
More features to explore
- Compliance to standards
- Allows improvement and development of local knowledge-base
- Analysis pipeline development & integration
- Custom database integration and development
- Optional integration of data into novoWorx for research purpose
- Custom analytics development
System Requirements
Basic requirements
Linux
64-bit operating system
Intel or AMD CPU
1024 x 768 display
Operating system
novoClinic is fully supported on the following operating systems:
| No. | Hardware | Minimum requirements |
|---|---|---|
| 1 | Central Processing Unit (CPU)
A single chipset can contain up to 64 physical cores, with 128 threads. On a dual socket server configuration, this will give you up to 256 threads at an all-core maximum clock speed of around 3.4GHz. |
AMD EPYC 7000 series
|
| 2 | Random Access Memory (RAM)
Aligned files that will be passed to the sorting algorithm will be sorted using memory buffers. The file is compressed and will be uncompressed in memory and will need at least 2GB of RAM per GB of Disk space to efficiently perform the sorting in as little time as possible. |
256 GB |
| 3 | Short Term Storage (Working Storage)
The ephemeral storage will be used to store transient files that are not kept beyond the lifetime of the individual patient analysis runtime. For ephemeral storage, it is recommended that the system utilize SSDs or NVME SSDs for maximum IO throughput. Due to the large sizes of the databases used, installation of the system itself will take up a minimum of 500 GB (depending on the number of databases and the size of the databases used). |
2 TB |
| 4 | Long Term Storage
For long term storage, the pipeline intermediary files may be removed and the input + final output files be stored at approximately 120GB per patient for WGS analysis, 10GB per patient for WES analysis and 1-5GB for Amplicon analysis, respectively. This will have to be multiplied by the number of patients that will be using the service . Our recommendation is based on data storage for 200 patients. |
24 TB (WGS)
2TB (WES) 1-5GB (Amplicon) |
